55be9034d4 Sci. CrossRefMedlineGoogle Scholar Mayor U., Guydosh N.R., Johnson C.M., Grossmann J.G., Sato S., Jas G.S., Freund S.M., Alonso D.O., Daggett V., Fersht A.R. Google Scholar Fersht A.R., Shi J.P., Knill-Jones J., Lowe D.M., Wilkinson A.J., Blow D.M., Brick P., Carter P., Waye M.M., Winter G. The late 1980s was a time of transition for Alan. When I joined his laboratory at Imperial College London in 1981, Alan had a Royal Society Research Professorship, a group of just four researchers, and following Perutz's advice, few or no committee duties. ISBN 3–540–13094–2 Previous article in issue: Methods of protein and nucleic acid research volume 2 immunoelectrophoresis, application of radioisotopes, by Lev A Osterman. By continuing to browse this site you agree to us using cookies as described in About Cookies Remove maintenance message . Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Navigate This Article Top References . At meetings, Alan always appeared to relish these encounters. He also describes his passion for chess and the contribution the game made to his intellectual training.
We would make small mutations that just deleted interactions between the enzyme and the substrate. My Account. I have always been struck by the extent to which Enzyme, Structure and Mechanism set out many of the ideas which subsequently formed the basis of Alan's outstanding research achievements in Protein Engineering. Calendar. Enzyme Structure and Mechanism. After 10 years at Imperial College London, he moved to Cambridge University as the Herchel Smith Professor of Organic Chemistry, a fitting appointment, and after 20 years of research into enzyme mechanism, he felt ready to take on new challenges As I have always been interested in uncovering general and universal principles rather than working on specific systems and thought that working on another [enzyme] would be an anticlimax after that wonderful enzyme [TyrRS], I turned to a new area for me but one which was perfect for the technology we had developed protein folding. He chose the ribonuclease barnase as his workhorse, an innocuous enzyme but a protein that had all the desirable attributes. Nature 1985;314:235-238. Although Alan is most closely associated with Cambridge, he spent 10 productive years at Imperial College London and the college is to be congratulated on publishing this volume of Selected Papers.